백서 치아발생에 락토페린이 미치는 영향
Effect of Lactoferrin on Tooth Development in Rats
박희수, 김현진,
소속 상세정보
박희수 ( Park Hee-Su ) - 원광대학교 치과대학 구강해부학교실
김현진 ( Kim Hyun-Jin ) - 원광대학교 치과대학 구강해부학교실
KMID : 0355820150360010037
Abstract
Among numerous studies related to lactoferrin, effect of lactoferrin involved with the bone formation have been recently noted. It was reported that lactoferrin increased the bone mass by enhancing the activity of the osteoblast as well as the proliferation of osteoblast and inhibiting the osteoclastic activity at the same time. In this study, we investigated the effect of lactoferrin during the tooth development in rats. Rats were divided into 3 groups: naked control, water, and lactoferrin. Naked control (NC) was left untouched, whereas the vehicle control group was injected with water that is the same amount with lactoferrin solution. Lactoferrin was injected daily and the dosage increased gradually by 4,6, 12 and 16 l返 per body weight (g) during postnatal 10 days. In the experimental group injected with 4 and 6 江寒， of lactoferrin, there was no significant difference compare to NC or vehicle control. However, more incisor eruption was occurred in the experimental group injected with 12 and 16 P送 of lactoferrin than that of NC or vehicle control. In order to elucidate the role of lactoferrin during the eruptive tooth movement, the further study will be needed.
키워드
락토페린; 뼈재구성; 뼈파괴세포; 치아; 맹출과정
lactoferrin; bone remodeling; osteoclast; tooth; eruptive movement
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